Product Availability Key

  • Mexico and Canada flagMexico and Canada
  •  Outside North America flag Outside North America
  •  US flag US
  • Mexico and Canada flag
  •  Outside North America flag
  •  US flag

CAT #: 23090050

BCL2/JH Tube A - Unlabeled for Gel Detection

Product Use

BCL2/JH Tube A – Unlabeled for Gel Detection is a Research Use Only master mix that can be used to identify IGH-BCL2 t(14;18) translocations.

Product Details

  • Description

    BCL2 translocations are reciprocal chromosome exchanges that place the bcl-2 proto-oncogene, located on chromosome 18, under aberrant transcriptional control of the immunoglobulin heavy chain gene, located on chromosome 14.  The bcl-2 protein is an antagonist to apoptosis (programmed cell death), a normal process designed to eliminate unneeded and damaged cells during hematopoiesis.  Increased expression of the bcl-2 protein leads to an increase in the levels of B-cells in the body.

    The BCL2/JH Tube A master mix targets the major breakpoint region (Mbr) of BCL2 translocations.  PCR products can be analyzed using standard gel electrophoresis using heteroduplex analysis with ethidium staining.

Legal Notice

Now Available

Our New Document Search Feature
SEARCH ⟶

Need Help Placing an Online Order?

Contact our Customer Service Team
CONTACT CUSTOMER SERVICE ⟶

Now Available

Our New Document Search Feature
SEARCH ⟶

Need Help Placing an Online Order?

Contact our Customer Service Team
CONTACT CUSTOMER SERVICE ⟶