CAT #: AML-MRD-MFC

AML MRD Assay by Multiparametric Flow Cytometry

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  • Description of Test:

    Measurable residual disease, also called “minimal residual disease” (MRD) refers to persistent leukemic cells in the blood or bone marrow of cancer patients during or after treatment. Undetected or untreated MRD is a major cause of cancer recurrence, hence sensitive MRD tests are needed to guide optimal treatment programs and provide prognostic indicators for risk stratification of patients.

    Flow cytometry has long been the standard of care for many blood cancers including acute myeloid leukemia (AML), but to achieve MRD level sensitivity with limited sample, powerful 12-color multiparametric flow cytometry (MFC) is needed. MFC is a state of the art method of MRD assessment that is widely used because it is highly sensitive, fast and cost-effective. The AML MRD Assay uses a comprehensive panel of antibody markers to characterize potential AML blast cells using a leukemia associated immunophenotype (LAIP) based different from normal (DfN) approach. This approach takes into account information from diagnosis, if available but also identifies aberrant cells that have differentiated from normal maturation without previous patient history. Use of up to 12-colors per tube enables the identification of more LAIPs using less sample previously available. Using a comprehensive selection of antibodies and a standardized panel across all time points, MRD populations can be characterized and tracked down to 0.01% sensitivity. 

    In addition to MRD monitoring, this panel’s extensive biomarker selection may be used to enroll and monitor subjects in clinical trials, thereby accelerating drug approvals. Interpretation subjectivity is minimized through standardized analysis software powered by state-of-the-art AI decision support technology and machine learning (ML).

  • Overview:

    AML MRD Assay biomarkers

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