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CAT #: 22070091

TCRG - 6FAM

Product Use

The TCRG – 6FAM is a Research Use Only master mix that can be used to identify T-Cell Receptor Gamma Chain Gene rearrangements.

Product Details

  • Description

    The human TCR gamma gene locus on chromosome seven (7q14) includes 14 V genes (six of these V genes are functional; three open reading frames and five pseudogenes) belonging to four subgroups (Group I, II, III and IV), five J segments and two C genes spread over 200 kilobases.  The diversity of this locus has complicated PCR-based testing.  Importantly, this master mix includes primers for all known groups of TCR gamma variable region genes and joining region genes.

    Amplification with all primers in a single tube has several additional important advantages over existing methods.  The polyclonal background that results from the combination of all primers in a single tube produces a more robust and easily interpreted signal with capillary electrophoresis, which aids in the interpretation of small peaks.  Competitive amplification of all TCRG gene rearrangements allows for identification of a quantitative threshold for a positive result and helps to avoid false positive results. The average size of the TCRG gene rearrangement PCR product is 190 bp, with a normal distribution of product sizes between 159 and 207 bp.

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