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CAT #: 13100010

BCR/ABL t(9;22) Translocation Assay for Gel Detection

Assay Use

This Research Use Only assay identifies BCR/ABL t(9;22) translocations.

Product Details

  • Summary and Explanation of the Test

    BACKGROUND
    BCR/ABL translocations are associated with a variety of hematologic malignancies.  The Philadelphia chromosome (Ph1) is a specific chromosomal abnormality that results from reciprocal t(9;22)(q34;ql1) chromosomal rearrangements fuse coding regions of the BCR gene, located on chromosome 22, with the ABL receptor-independent tyrosine kinase gene on chromosome 9.  This assay detects and identifies the variety of p190-, p210- and p230-type transcripts produced from all known BCR/ABL translocations.

    SUMMARY
    The master mixes are included in these assay kits used to amplify complementary DNA (cDNA) produced from specimen(s), and positive and negative RNA controls (included). Primers target an internal control transcript (Abl) and p190-, p210-, and p230-type transcripts expressed from BCR-ABL1 translocations.  Amplicon products can be analyzed by capillary electrophoresis or standard gel electrophoresis with ethidium bromide staining.  This assay is compatible with all standard RNA extraction and cDNA synthesis methods.

     

  • Specimen Requirements

    This assay tests complementary DNA (cDNA) template.

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