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CAT #: 22070031

TCRG Tube A - 6FAM & HEX for ABI Fluorescence Detection

Product Use

The TCRG Tube A – 6FAM & HEX for ABI Fluorescence Detection is a Research Use Only master mix that can be used to identify T-cell receptor gamma chain gene rearrangements.

Product Details

  • Description

    The T-cell receptor gamma (TCRG) chain locus spans 160 kb on chromosome 7 (7p14).  Rearrangement of the variable (Vγ) and joining (Jγ) genetic segments of the TCRG locus result in Vγ-Jγ products of unique length and sequence.  The TCRG locus does not contain D segments.  Additionally, the TCRG gene contains a limited number of Vγ and Jγ segments such that the amplification of all major Vγ-Jγ combinations is possible with four Vγ and two Jγ primers.

    This master mix targets conserved regions within the variable (Vγ) and joining (Jγ) regions that flank the unique, hypervariable, antigen-binding, complementarity determining region 3 (CDR3), containing two (2) Vγ primers and two (2) Jγ primers.  Clonality is indicated if any clonal band(s) are generated.  PCR products are differentially labeled with 6FAM & HEX and can be analyzed using any platform that has the ability to detect these fluorochromes.

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