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CAT #: 43100100

Proficiency Panel for the BCR/ABL t(9;22) Translocation Assay

Product Use

Invivoscribe’s RNA Controls and Panels are intended for validation by the end user for use in molecular assays.  These controls are specific to gene rearrangements, mutations, and/or translocations from human RNA.

Product Details

  • Description

    This 10 member panels consists of 100% clonal control RNA extracted from three BCR/ABL positive cell lines as well as 10-2 (1:100) and 10-4 (1:10,000) dilutions (v/v) of these positive RNAs diluted into a normal (BCR/ABL negative) control RNA, IVS-0035 Clonal Control RNA. A sample of 100% IVS-0035 Clonal Control RNA is also included. All three cell lines (IVS-0003, IVS-0011, and IVS-0032) carry a t(9;22) translocation. One of the cell lines, IVS-0032, encodes for p190-type (ALL-associated) transcripts with e1a2 junctions. The other two cell lines both encode for p210-type (CML-associated) transcripts. One of the p210-type translocations, IVS-0003, harbors a b2a2 junction and the other, IVS-0011, harbors a b3a2 junction. This proficiency panel is used to validate tests that identify BCR/ABL t(9;22) translocations and is designed to be used with the BCR/ABL t(9;22) Translocation Assay Kits.

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