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CAT #: 13110010

PML/RARα t(15;17) Translocation Assay for Gel Detection

Product Use

This Research Use Only assay identifies PML/RARα t(15;17) translocations.

Product Details

  • Summary and Explanation of the Test

    Three PML/RARα translocation patterns have been identified in samples with acute myelogenous leukemia (AML): type A is the short (S-form); the breakpoint occurs within breakpoint cluster region 3 (Bcr-3).  Type B is the long (L-form); the breakpoint occurs within Bcr-1.  There is a third type B variant or variable (V-form); the breakpoint is within Bcr-2.  Identification of the PML/RARα t(15;17) rearrangements are commonly used in the study of APL because it is correlated with responsiveness to treatment.  This RT-PCR method directly identifies the chimeric PML/RARα transcripts expressed from all three forms of PML/RARα translocations.

  • Specimen Requirements

    This assay tests complementary DNA (cDNA) template.  Please refer to the IFU for protocols on extracting RNA and making cDNA.

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