CAT #: 23100071
BCR/ABL t(9;22) Mix 3b - 6FAM for ABI Fluorescence Detection
BCR/ABL t(9;22) Mix 3b – 6FAM for ABI Fluorescence Detection is a Research Use Only master mix that can be used to identify BCR/ABL t(9;22) translocations.
BCR/ABL translocations are associated with a variety of hematologic malignancies. The Philadelphia chromosome (Ph1) is a specific chromosomal abnormality that results from reciprocal t(9;22)(q34;ql1) chromosomal rearrangements fuse coding regions of the BCR gene, located on chromosome 22, with the ABL receptor-independent tyrosine kinase gene on chromosome 9.
The BCR/ABL t(9;22) Mix 3b master mix targets all p210- and p230-type BCR/ABL transcripts. PCR products are differentially labeled with 6FAM and can be analyzed using any platform that has the ability to detect these fluorochromes.
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