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CAT #: 23100041

BCR/ABL t(9;22) Mix 1b - HEX for ABI Fluorescence Detection

Product Use

BCR/ABL t(9;22) Mix 1b – HEX for ABI Fluorescence Detection is a Research Use Only master mix that can be used to identify BCR/ABL t(9;22) translocations.

Product Details

  • Description

    BCR/ABL translocations are associated with a variety of hematologic malignancies.  The Philadelphia chromosome (Ph1) is a specific chromosomal abnormality that results from reciprocal t(9;22)(q34;ql1) chromosomal rearrangements fuse coding regions of the BCR gene, located on chromosome 22, with the ABL receptor-independent tyrosine kinase gene on chromosome 9.

    The BCR/ABL t(9;22) Mix 1b master mix targets the Abl gene, serving as an internal control.  PCR products are differentially labeled with HEX and can be analyzed using any platform that has the ability to detect these fluorochromes.

     

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