CAT #: 23090020
BCL2/JH t(14;18) (mcr) Mix 2b - Unlabeled for Gel Detection
BCL2/JH t(14;18) (mcr) Mix 2b – Unlabeled for Gel Detection is a Research Use Only master mix that can be used to identify IGH-BCL2 t(14;18) translocations.
BCL2 translocations are reciprocal chromosome exchanges that place the bcl-2 proto-oncogene, located on chromosome 18, under aberrant transcriptional control of the immunoglobulin heavy chain gene, located on chromosome 14. The bcl-2 protein is an antagonist to apoptosis (programmed cell death), a normal process designed to eliminate unneeded and damaged cells during hematopoiesis. Increased expression of the bcl-2 protein leads to an increase in the levels of B-cells in the body.
The BCL2/JH t(14;18) (mcr) Mix 2b master mix targets the minor cluster region (mcr) of BCL2-mcr translocations. PCR products can be analyzed using standard gel electrophoresis using heteroduplex analysis with ethidium staining.
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